Haifu System has been used in clinical practice for over two decades with the number of patients treated reaching 151,975 as of December, 2019. Hundreds of academic papers have been published and have shown that the safety and effectiveness of HIFUtreatment (performed using Haifu System) for both benign and malignant tumors have been shown in hundreds of academic papers. For example, a large 20-center prospective cohort study ledbyProf. LANG Jinghe, Academician of Chinese Academy of Engineering and President of Chinese Obstetricians and Gynecologists Association (COGA), enrolling 2,411 patients with symptomatic fibroids across 20 Chinese hospitals, showed that HIFU ablation (n=1,353) hada similar effect to myomectomy (n=586) and hysterectomy (n=472), but a better safety profile with minimal injury, remarkable symptom relief, improvement of quality of life of patients, considerable shorter hospital stay and lower medical costs. A retrospective case series of

9,988 patients with uterine fibroids (7,438 patients) or adenomyosis (2,549 patients) showed that HIFU ablation for uterine fibroids and adenomyosis is highly effective and safe with light and temporary adverse reactions under conscious sedation, hence an alternative treatment for women with uterine fibroids and adenomyosis. A retrospective case series of 27,053 patients with uterine fibroids (n=17,402), adenomyosis (n=8434), caesarean scar pregnancy (n=876), or placenta accreta (n=341) showed that HIFU is safe in treating patients with benign uterine diseases with low rate of major adverse effects. In addition, HIFUablation for uterine fibroids has been included into the Guidance of National Institute for Health and Care Excellence (NICE Guidance), UK and other international clinical guidelines respectively by the American College of Obstetricians and Gynecologists (ACOG), theSociety of Obstetricians and Gynaecologists of Canada (SOGC), the Korean Society Of Obstetrics and Gynecology (KSOG), and the Chinese Obstetricians and Gynecologists Association (COGA).

The HIFU treatment performed using Haifu System is under the real-time guidance of ultrasound, which means the treatment effect can be seen in a real-time manner and thus the treatment scope and intensity can be adjusted according to the patient’s reaction to the treatment. In addition, as there is no need of general anesthesia or spinal anesthesia duringHIFU treatment of uterine fibroids and adenomyosis and a small amount of sedatives and analgesics will suffice, the patient can communicate with the medical professionals all along the treatment if any discomfort. And medical professionals are also by the side of the patient all the time observing vital signs and hence coping with any situations that may occur in a timely manner. And therefore, the HIFU treatment process is safe and reliable.

The advantages of the Haifu System: 1. no cutting open, no puncturing, no bleeding, less pain, quick recovery and the patient can get out of bed 2 hours after HIFU treatment; 2. no need of general anesthesia or spinal anesthesia in the treatment of benign tumors; 3. the treatment is not subject to the size and shape of tumors; 4. organ-preserving without damaging other normal tissues; 5. usually one single session of ablation treatment will suffice; 6. short treatment time and quick recovery; 7. no radiation; 8. repetitive interventions are plausible.